Representative Papers
Apr. 2014
Comparison of 99m Tc-TRODAT-1 SPECT and 18 F-AV-133 PET Imaging in Healthy Controls and Parkinson’s Disease Patients
IT Hsiao, YH Weng, WY Lin, CJ Hsieh, SP Wey, TC Yen, MP Kung, CS Lu, and KJ Lin.
Nuclear medicine and biology. Apr 2014. 41(4):322-9.
(99m)Tc-TRODAT-1 is the first clinical routine (99m)Tc radiopharmaceutical to evaluate dopamine neurons loss in Parkinson's disease (PD). (18)F-AV-133 is a novel PET radiotracer targeting the vesicular monoamine transporter type 2 (VMAT2) to detect monoaminergic terminal reduction in PD patients. The aim of this study is to compare both images in the same health control (HC) and PD subjects.
Jun. 2014
Correlation of Parkinson Disease Severity and [18F]-FP-(+)-DTBZ Positron Emission Tomography
IT Hsiao, YH Weng, CJ Hsieh, WY Lin, SP Wey, MP, Kung, TC Yen, CS Lu, KJ Lin.
JAMA Neurology., JAMA Neurology. 2014 Jun 1;71(6):758-66.
Currently, diagnosis of Parkinson disease is mainly based on clinical criteria characterized by motor symptoms including bradykinesia, rigidity, resting tremor, and postural instability. Reliable in vivo biomarkers to monitor disease severity and reflect the underlying dopaminergic degeneration are important for future disease-modifying therapy in Parkinson disease.
Jun. 2013
Perfusion-like template and standardized normalization-based brain image analysis using 18F-florbetapir (AV-45/Amyvid) PET
Ing-Tsung Hsiao, Chin-Chang Huang, Chia-Ju Hsieh, Shiaw-Pyng Wey, Mei-Ping Kung, Tzu-Chen Yen, Kun-Ju Lin
Eur J Nucl Med Mol Imaging. 2013 Jun;40(6):908-20.
Amyloid positron emission tomography (PET) is an important noninvasive method for detecting amyloid burden in Alzheimer's disease (AD) patients. As amyloid PET images have limited anatomical information, magnetic resonance (MR) imaging is usually acquired to perform reliable spatial normalization needed for large-scale analysis. This work proposed and evaluated the performance of new MR-free spatial normalization methods using a perfusion-like template for amyloid PET imaging.